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Venue

Costão do Santinho Resort
Estr. Ver. Onildo Lemos, 2505
Praia do Santinho
Florianóplis - SC, Brazil

+55-11-2627-9427

Scientific Program

XIV CONGRESS OF THE BRAZILIAN SOCIETY OF TOXINOLOGY

SUNDAY, AUGUST 27, 2017

19:30 h                 OPENING CEREMONY

19:45 h                 OPENING CONFERENCE                             

A Role for Snake Envenomation Wound Exudate in Systemically Observed Pathologies

Jay Fox, Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Virginia, USA

Chair: Denise V. Tambourgi, Instituto Butantan, SP, Brazil

20:30 h                 WELCOME RECEPTION - Cascaes Center, Costão do Santinho Resort

 

MONDAY, AUGUST 28, 2017

7:30 – 8:15 h          COURSE - Crystallization of Toxins: from Structure to Function 

Coordinator: Marcos Roberto de Mattos Fontes, Universidade Estadual Paulista, SP, Brazil

08:30 – 10:15 h                 SESSION I            SNAKES: FROM BIOLOGY TO VENOMS

Chairs: Nelson Jorge da Silva, Pontifícia Universidade Católica de Goiás, GO, Brazil; Ana Moura da Silva, Instituto Butantan, SP, Brazil

08:30 hBeak of the snake: conceptual frameworks and functional tests of venom as an adaptive phenotype

Lisle Gibbs, Department of Evolution, Ecology and Organismal Biology, Ohio State University, Ohio, USA

08:55 h Insights on mechanisms and effects of individual variability in venoms of  Bothrops atrox snakes

Ana Moura da Silva, Instituto Butantan, SP, Brazil

09:20 h Coralsnake venoms: fools rush in where angels fear to tread

Nelson Jorge da Silva, Pontifícia Universidade Católica de Goiás, GO, Brazil

09:45 h Proteomic studies of venom variability and ontogeny of neuwiedi group from Southeastern and Southern regions of Brazil

Jessica Matos Kleiz Ferreira, Universidade Federal do Rio de Janeiro, RJ, Brazil

10:00 hCan diet influence venom composition in genus Bothrops

Nathália Galizio, Instituto Butantan, SP, Brazil

10:15 – 10:45 h                 COFFEE BREAK

10:45 – 11:25 h                 PLENARY LECTURE I        

Chair: Inácio Junqueira de Azevedo, Instituto Butantan, SP, Brazil

Taxonomy and Biogeography of New World Snakes

Christopher L. Parkinson, Department of Biology, University of Central Florida, FL, USA

11:30 - 13:00 h                  SESSION II         SYSTEMS BIOLOGY: INVESTIGATING TOXINS MECHANISMS 

Chairs: Richard Valente, Instituto Oswaldo Cruz, Fiocruz, RJ, Brazil; Denise V. Tambourgi, Instituto Butantan, SP, Brazil

11:30 hSnake venom peptidome (cryptome): a rich bioactive peptide library?

Richard Valente, Instituto Oswaldo Cruz, Fiocruz, RJ, Brazil

11:55 hClass P1 metalloproteinase from Bothrops pirajai venom induces leukocyte activation, which is partially Complement dependent: similarities to endotoxic shock

Denise V. Tambourgi, Instituto Butantan, SP, Brazil

12:20 hTityus serrulatus cryptome: unveiling cryptides with cardiovascular activity

Thiago V. Braga, Universidade Federal de Minas Gerais, MG, Brazil

12:45 hCPP-Ts: a new toxin from Tityus serrulatus venom modulating intracellular Ca2+ release and a promising tool for intranuclear delivery

Bárbara Bruna Ribeiro de Oliveira Mendes, Universidade Federal de Minas Gerais, MG, Brazil

13:00 h                              LUNCH

15:00 – 15:40 h                 PLENARY LECTURE II      

Chair: Marcelo R.V. Diniz, Fundação Ezequiel Dias, MG, Brazil

Synergism Among Genomic, Transcriptomic, and Proteomic Approaches to the Study of Venom Composition and evolution

Darin R. Rokyta, Florida State University, Department of Biological Science, Tallahassee, FL, USA

15:45 – 17:10 h                 SESSION III                                        OMICS AND EVOLUTION

Chairs: Gilberto B. Domont, Universidade Federal do Rio de Janeiro, RJ, Brazil; Inácio Junqueira de Azevedo, Instituto Butantan, SP, Brazil

15:45 h - What the genomic contexts of toxin genes can tell about the evolution of snake venom?

Inácio Junqueira de Azevedo, Instituto Butantan, SP, Brazil

16:10 h - Crotoxin multiproteoform complexes by top-down proteomics

Gilberto B. Domont, Universidade Federal do Rio de Janeiro, RJ, Brazil

16:35 h - High performance mass spectrometry applied to the study of spiders and anurans toxins

Wagner Fontes, Universidade de Brasília, DF, Brazil

17:00 h - Sequence Slider: tackling sequence uncertainty in crystallographic structure elucidation with mass spectrometry and phylogenetic analysis

Rafael Junqueira Borges, Universidade Estadual de São Paulo, SP, Brazil

17:15 - 17:45 h                  COFFEE BREAK

17:30 - 19:00 h                  POSTER SESSION I

19:00 - 21:00 h                  EXTRAORDINARY ASSEMBLY OF THE SBTx

 

TUESDAY, AUGUST 29, 2017

7:30 – 8:15 h                  COURSE            Crystallization of Toxins: from Structure to Function 

Coordinator: Marcos Roberto de Mattos Fontes, Universidade Estadual Paulista, SP, Brazil

08:30 – 10:20 h                 SESSION IV       ARTHROPODS: VENOMS AND MECHANISMS

Chairs: Mario Sergio Palma, Universidade Estadual de São Paulo, SP, Brazil; Maria Elena de Lima, Universidade Federal de Minas Gerais, MG, Brazil

08:30 h - A synthetic peptide derived from a spider toxin as therapeutic approach to treat erectile dysfunction. A technology transfer

Maria Elena de Lima, Universidade Federal de Minas Gerais, MG, Brazil

08:55 h - Revealing the unconventional toxinomics of the venom from the social wasp Polybia paulista

Mario Sergio Palma, Universidade Estadual de São Paulo, SP, Brazil

09:20  h - Eicosanoids regulate scorpion venom-induced inflammasome activation in mice and human cells

Lúcia Helena Faccioli, Universidade de São Paulo, Campus Ribeirão Preto, SP, Brazil

09:45  h - In-depth characterization of HelaTx1, a scorpion toxin targeting Kv channels

Steve Peigneur, University of Leuven, Leuven, Belgium

10:10 h - An outlook of scorpion venoms proteases: isolation and biochemical characterization of metalloproteases from Tityus serrulatus venom

Daniela Cajado-Carvalho, Instituto Butantan, SP, Brazil

______________________________________________________________________________________________________________

10:25 - 10: 50 h                  COFFEE

10:50 – 11:30 h                 PLENARY LECTURE III     

Chair: Celia Regina Ribeiro da Silva Carlini, Pontifícia Universidade Católica do Rio Grande do Sul, RS, Brazil

Martentoxin: from Foundation Research to Drug Development. Ji Yong-Hua, Shanghai University, Shanghai, China

11: 30 – 13:00 h                SESSION V          TOXINS INHIBITORS

Chairs: Consuelo Latorre Fortes-Dias, Fundação Ezequiel Dias MG, Brazil; Jonas Perales, Instituto Oswaldo Cruz, Fiocruz, RJ, Brazil

11:30 h - Natural inhibitors of snake venoms toxins: an overview focused in its structural characteristics and action mechanism

Jonas Perales, Instituto Oswaldo Cruz, Fiocruz, RJ, Brazil

11:55 h - Phospholipase A2 inhibitors from snakes

Consuelo Latorre Fortes-Dias, Fundação Ezequiel Dias, MG, Brazil

12:20 h - Medicinal plants from Northeastern Brazil as a complement to snake antivenom therapy: case of the species from the genus Jatropha (Euphorbiaceae)

Matheus de Freitas Fernandes-Pedrosa, Universidade Federal do Rio Grande do Norte, RN, Brazil

12:45 h - One step closer to understanding the interaction between BJ46a and Jararhagin by resorting to cross-linking-MS and integrative modeling

Viviane de Almeida Bastos, Instituto Oswaldo Cruz, Fiocruz, RJ, Brazil

13:00 h                              LUNCH

14:20 – 15:20 h                  SESSION VI         AQUATIC AND AMPHIBIAN ANIMAL TOXINS

Chairs: Yara Cury, Instituto Butantan, SP, Brazil; Vidal Haddad Junior, Universidade Estadual Paulista, SP, Brazil

14:20 h - Use of clinical evidence of envenoming caused by aquatic animals as an initial step towards the study of toxins: a logical path

Vidal Haddad Junior, Universidade Estadual Paulista, SP, Brazil

14:45 h - Multiple functional therapeutic effects of TnP: a small stable synthetic peptide derived from Thalassopryhen nattereri fish venom in a mouse model of multiple sclerosis

Mônica Lopes Ferreira, Instituto Butantan, SP, Brazil

15:10 h - Anurans antimicrobial peptides as a multifunctional class of toxins

Mariana S. Castro, Universidade de Brasília, DF, Brazil

15:35 – 16:15 h                  PLENARY LECTURE IV    

Chair: Luis Roberto de Camargo Gonçalves, Instituto Butantan, SP, Brazil

Venoms to Drugs: Spider-venom Peptides for the Treatment of Pain, Epilepsy, and Stroke

Glenn King, The University of Queensland, Queensland, Australia

16:15 – 17:30 h                  PANEL DISCUSSION I     INNOVATION

Chair: Ana Marisa Chudzinski Tavassi, Instituto Butantan, SP, Brazil

Debaters

16:15 h - Ana Marisa Chudzinski Tavassi, Instituto Butantan, SP, Brazil

16:30 h - Norberto Rech, Universidade Federal de Santa Catarina, SC, Brazil

16:45 h - Gilberto Gonçalves, GAG Investimentos, SP, Brazil

17:00 h - General discussion

17:30 - 18:00 h                  COFFEE BREAK

17:30 - 19:00 h                  POSTER SESSION II

20:30 h                                SBTx PARTY

 

WEDNESDAY, AUGUST 30, 2017

08:00 – 8:45 h                  COURSE            Crystallization of Toxins: from Structure to Function 

Coordinator: Marcos Roberto de Mattos Fontes, Universidade Estadual Paulista, SP, Brazil

09:00 - 10:30 h                 PANEL DISCUSSION II    PRACTICE IN CLINICAL ENVENOMATION 

Chair: Marlene Zannin, Universidade Federal de Santa Catarina, SC, Brazil; Fabio Bucaretchi, Universidade de Campinas, SP, Brazil

Debaters

09:00 h - Fabio Bucaretchi, Universidade de Campinas, SP, Brazil

09:30 h - Cinthia Kunze Rodrigues, Centro de Informações Toxicológicas de Santa Catarina, SC, Brazil

10:00 h - Palmira Cupo, Universidade de São Paulo, SP, Brazil

10:30 – 11:30 h                COFFEE BREAK / SBTX JOVEM ACTIVITY

11:30 – 12:10 h                PLENARY LECTURE V      

Chair: Roxane Maria Fontes Piazza, Instituto Butantan, SP, Brazil

With Translated Targeting Ability, an Exotoxin Behaved as a Safe and Efficient Antibiotic

Qiu Xiao-Qing, Sichuan University, Chengdu, China

12:10 – 13:00 h                SBTX INTERNATIONALIZATION

Chair: Denise V. Tambourgi, Instituto Butantan, SP, Brazil

12:10 h - International Toxinology Socitey. Jay Fox, President

12:25 h - Toxicon. Glenn King, Chief Editor

12:40 h - General discussion

13:00 - 14:00 h                   LUNCH

14:30 - 16:00 h                   SESSION VII       CROTOXIN: CELEBRATING 80 YEARS OF DISCOVERY

Chairs: Marcos Fontes, Universidade Estadual Paulista, SP, Brazil; Gisele Picolo, Instituto Butantan, SP, Brazil

14:30 h - 80 years of Crotoxin - Insights into its toxic mechanism revealed by recent structural studies

Marcos Fontes, Universidade Estadual Paulista, SP, Brazil

14:55 h - Crotoxin and its immunomodulatory effect: Interference in the development of the experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis

Gisele Picolo, Instituto Butantan, SP, Brazil

15:20 h - Clinical use of Crotoxin. Paul F. Reid, Celtic Biotech Inc., IA, USA

15:45 h - Crotoxin, a phospholipase A2 from Crotalus durissus terrificus rattlesnake venom, attenuates coagulation and inflammatory parameters in endotoxin-induced disseminated intravascular coagulation

Marcos Aurelio Sartim, Universidade de São Paulo, SP, Brazil

16:00 h                             CLOSE SECTION AND AWARDS

 

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